The utility of diffusion-weighted MR imaging for differentiating uterine sarcomas from benign leiomyomas

被引:264
作者
Tamai, Ken [2 ]
Koyama, Takashi [1 ]
Saga, Tsuneo [2 ]
Morisawa, Nobuko [2 ]
Fujimoto, Koji [2 ]
Mikami, Yoshiki [3 ]
Togashi, Kaori [2 ]
机构
[1] Kyoto Univ Hosp, Dept Radiol, Sakyo Ku, Kyoto 6068507, Japan
[2] Kyoto Univ, Grad Sch Med, Dept Diagnost Imaging & Nucl Med, Kyoto, Japan
[3] Kyoto Univ Hosp, Anat Pathol Lab, Kyoto 606, Japan
关键词
uterus; magnetic resonance; neoplasm; apparent diffusion coefficient; myometrium;
D O I
10.1007/s00330-007-0787-7
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
The usefulness of diffusion-weighted (DW) magnetic resonance (MR) imaging for the diagnosis of uterine sarcomas was investigated, as well as whether DW images and quantitative measurement of apparent diffusion coefficient (ADC) values can facilitate differentiating uterine sarcomas from benign leiomyomas. MR images including DW images were obtained in 43 surgically treated patients with 58 myometrial tumors, including seven uterine sarcomas (five leiomyosarcomas and two endometrial stromal sarcomas) and 51 benign leiomyomas (43 ordinary leiomyomas, two cellular leiomyomas and six degenerated leiomyomas). Qualitative analysis of non-enhanced and postcontrast MR images and DW images and quantitative measurement of ADC values were performed for each myometrial tumor. Both uterine sarcomas and cellular leiomyomas exhibited high signal intensity on DW images, whereas ordinary leiomyomas and most degenerated leiomyomas showed low signal intensity. The mean ADC value (10(-3) mm(2)/s) of sarcomas was 1.17 +/- 0.15, which was lower than those of the normal myometrium (1.62 +/- 0.11) and degenerated leiomyomas (1.70 +/- 0.11) without any overlap; however, they were overlapped with those of ordinary leiomyomas and cellular leiomyomas. In addition to morphological features on nonenhanced and postcontrast MR sequences, DW imaging and ADC measurement may have a potential ability to differentiate uterine sarcomas from benign leiomyomas.
引用
收藏
页码:723 / 730
页数:8
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