Dendritic cells: their significance in health and disease

被引：31

作者：

Keller, R ^{[1
]}

机构：

[1] Univ Zurich, Inst Expt Immunol, Dept Pathol, CH-8091 Zurich, Switzerland

来源：

IMMUNOLOGY LETTERS | 2001年 / 78卷 / 03期

关键词：

the dendritic cell system; dendritic cell trafficking and maturation; antigen capture and presentation by dendritic cells; dendritic cells in clinically relevant situations;

D O I：

10.1016/S0165-2478(01)00247-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dendritic cells (DCs) represent a heterogenous population of professional antigen-presenting cells. Precursor cells move via the blood to peripheral tissues. These immature DCs can take up invading pathogens and then rapidly migrate to the draining secondary lymphoid organs. Converted into antigen-presenting mature DCs, these cells are able to prime naive T cells and to initiate an adoptive immune response. The extraordinary functional profile suggests that, under certain preconditions, DCs may represent an ideal vector in the immunotherapy of cancer and infectious diseases (C) 2001 Elsevier Science BN. All rights reserved.

引用

页码：113 / 122

页数：10

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