Stereoselective reduction of ketones by Daucus carota hairy root cultures

被引：31

作者：

Caron, D

Coughlan, AP

Simard, M

Bernier, J

Piché, Y

Chênevert, R

机构：

[1] Univ Laval, Fac Sci & Genie, Dept Chim, CREFSIP, Quebec City, PQ G1K 7P4, Canada

[2] Univ Laval, Fac Foresterie & Geomat, Ctr Rech Biol Forestiere, Dept Sci Bois & Foret, Quebec City, PQ G1K 7P4, Canada

来源：

BIOTECHNOLOGY LETTERS | 2005年 / 27卷 / 10期

基金：

加拿大自然科学与工程研究理事会;

关键词：

acetophenone; Daucus carota; hairy root culture; (S)-phenylethanol; stereoselective reduction;

D O I：

10.1007/s10529-005-5187-y

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Reduction of acetophenone by Daucus carota hairy root cultures afforded (S)-phenylethanol in high yield (96%) and excellent enantiomeric excess (ee >= 98%). Aromatic ketones, keto esters, and a simple aliphatic ketone were reduced with good stereoselectivity (ee = 62-98%) and moderate to high chemical yields (25-90%).

引用

页码：713 / 716

页数：4

共 14 条

[1] BIOCATALYTIC PREPARATION OF CHIRAL ALCOHOLS BY ENANTIOSELECTIVE REDUCTION WITH IMMOBILIZED CELLS OF CARROT [J].