Facilitated Cross-Species Transmission of Prions in Extraneural Tissue

被引:109
作者
Beringue, Vincent [1 ]
Herzog, Laetitia [1 ]
Jaumain, Emilie [1 ]
Reine, Fabienne [1 ]
Sibille, Pierre [1 ]
Le Dur, Annick [1 ]
Vilotte, Jean-Luc [2 ]
Laude, Hubert [1 ]
机构
[1] INRA, UR892, F-78350 Jouy En Josas, France
[2] INRA, UMR1313, F-78350 Jouy En Josas, France
关键词
TRANSGENIC MICE; VARIANT CJD; SCRAPIE AGENT; PROTEIN; STRAINS; DISEASE; BSE; PATHOGENESIS; PREVALENCE; PHENOTYPE;
D O I
10.1126/science.1215659
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Prions are infectious pathogens essentially composed of PrPSc, an abnormally folded form of the host-encoded prion protein PrPC. Constrained steric interactions between PrPSc and PrPC are thought to provide prions with species specificity and to control cross-species transmission into other host populations, including humans. We compared the ability of brain and lymphoid tissues from ovine and human PrP transgenic mice to replicate foreign, inefficiently transmitted prions. Lymphoid tissue was consistently more permissive than the brain to prions such as those causing chronic wasting disease and bovine spongiform encephalopathy. Furthermore, when the transmission barrier was overcome through strain shifting in the brain, a distinct agent propagated in the spleen, which retained the ability to infect the original host. Thus, prion cross-species transmission efficacy can exhibit a marked tissue dependence.
引用
收藏
页码:472 / 475
页数:4
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