Wnt Trafficking: New Insights into Wnt Maturation, Secretion and Spreading

被引：119

作者：

Port, Fillip ^{[1
]}

Basler, Konrad ^{[1
]}

机构：

[1] Inst Mol Life Sci, CH-8057 Zurich, Switzerland

来源：

TRAFFIC | 2010年 / 11卷 / 10期

基金：

瑞士国家科学基金会;

关键词：

exosomes; lipid modification; morphogen gradient; retromer; Wnt secretion; Wntless; WINGLESS MORPHOGEN GRADIENT; LONG-RANGE ACTION; REQUIRES RETROMER; TRANSMEMBRANE PROTEIN; LIPOPROTEIN PARTICLES; LIPID-MODIFICATION; C-ELEGANS; DROSOPHILA; CELLS; PORCUPINE;

D O I：

10.1111/j.1600-0854.2010.01076.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Proteins of the Wnt family are secreted signaling molecules that regulate multiple processes in animal development and control tissue homeostasis in the adult. Wnts spread over considerable distances to regulate gene expression in cells located at distant sites. Paradoxically, Wnts are poorly mobile because of their posttranslational modification with lipids. Recent evidence suggests that several pathways exist that are capable of transforming hydrophobic, insoluble Wnts into long-range signaling molecules. Furthermore, the discovery of Wntless as a protein specifically required for the secretion of Wnt suggests that Wnt trafficking through the secretory pathway is already under special scrutiny. Here, we review recent data on the molecular machinery that controls Wnt secretion and discuss how Wnts can be mobilized for long-range signaling.

引用

页码：1265 / 1271

页数：7

共 51 条

[1] Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells [J].