Additional cytotoxic polyacetylenes from the marine sponge Petrosia species

被引：24

作者：

Lim, YJ

Park, HS

Im, KS

Lee, CO

Hong, J

Lee, MY

Kim, DK

Jung, JH ^{[1
]}

机构：

[1] Pusan Natl Univ, Coll Pharm, Pusan 609735, South Korea

[2] Korea Res Inst Chem Technol, Taejon 305606, South Korea

[3] Korea Basic Sci Inst, Taejon, South Korea

[4] Inje Univ, Dept Chem, Kimhae, South Korea

来源：

JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 01期

关键词：

D O I：

10.1021/np000252d

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Ten new polyacetylenic alcohols (1-6, 8-11), along with a known compound, petrocortyne C (7), were isolated from the marine sponge Petrosia sp. The gross structures were established based on NMR and MS data, and the absolute configuration was determined by the modified Mosher's method. These compounds displayed considerable cytotoxicity against a small panel of human solid tumor cell lines. Compounds 1-11 were further evaluated for in vitro inhibitory activity on DNA replication.

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页码：46 / 53

页数：8

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