Cysteinyl leukotrienes in allergic inflammation - Strategic target for therapy

被引：110

作者：

Busse, W

Kraft, M

机构：

[1] Univ Wisconsin, Sch Med, Dept Med, Madison, WI 53792 USA

[2] Natl Jewish Med & Res Ctr, Denver, CO USA

来源：

CHEST | 2005年 / 127卷 / 04期

关键词：

asthma; cytokines; eosinophils; inflammation; leukotrienes; leukotriene receptor antagonists; remodeling; rhinitis;

D O I：

10.1378/chest.127.4.1312

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Systemically bioavailable leukotriene receptor antagonists (LTRAs) can reduce the essential components of allergic inflammation in allergic rhinitis (AR) and asthma by blocking cysteinyl leukotriene (CysLT) activity, resulting in a wide range of clinical effects. CysLTs, mediators, and modulators in the pathophysiology of asthma and AR are a key target for therapy because they modulate production of hemopoietic progenitor cells, survival and recruitment of eosinophils to inflamed tissue, activity of cytokines and chemokines, quantity of exhaled NO, smooth-muscle contraction, and proliferation of fibroblasts. The mechanism of action of LTRAs leads to their effects on systemic allergic inflammatory processes.

引用

收藏

页码：1312 / 1326

页数：15

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