Cysteinyl leukotrienes in allergic inflammation - Strategic target for therapy

被引：110

作者：

Busse, W

Kraft, M

机构：

[1] Univ Wisconsin, Sch Med, Dept Med, Madison, WI 53792 USA

[2] Natl Jewish Med & Res Ctr, Denver, CO USA

来源：

CHEST | 2005年 / 127卷 / 04期

关键词：

asthma; cytokines; eosinophils; inflammation; leukotrienes; leukotriene receptor antagonists; remodeling; rhinitis;

D O I：

10.1378/chest.127.4.1312

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Systemically bioavailable leukotriene receptor antagonists (LTRAs) can reduce the essential components of allergic inflammation in allergic rhinitis (AR) and asthma by blocking cysteinyl leukotriene (CysLT) activity, resulting in a wide range of clinical effects. CysLTs, mediators, and modulators in the pathophysiology of asthma and AR are a key target for therapy because they modulate production of hemopoietic progenitor cells, survival and recruitment of eosinophils to inflamed tissue, activity of cytokines and chemokines, quantity of exhaled NO, smooth-muscle contraction, and proliferation of fibroblasts. The mechanism of action of LTRAs leads to their effects on systemic allergic inflammatory processes.

引用

收藏

页码：1312 / 1326

页数：15

相关论文

共 115 条

[81] Protection from pulmonary fibrosis in leukotriene-deficient mice [J].

Peters-Golden, M ;

Bailie, M ;

Marshall, T ;

Wilke, C ;

Phan, SH ;

Toews, GB ;

Moore, BB .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2002, 165 (02) :229-235

[82] REGULATION OF MACROPHAGE-DERIVED FIBROBLAST GROWTH-FACTOR RELEASE BY ARACHIDONATE METABOLITES [J].

PHAN, SH ;

MCGARRY, BM ;

LOEFFLER, KM ;

KUNKEL, SL .

JOURNAL OF LEUKOCYTE BIOLOGY, 1987, 42 (02) :106-113

[83] BINDING OF LEUKOTRIENE-C4 TO RAT LUNG FIBROBLASTS AND STIMULATION OF COLLAGEN-SYNTHESIS INVITRO [J].

PHAN, SH ;

MCGARRY, BM ;

LOEFFLER, KM ;

KUNKEL, SL .

BIOCHEMISTRY, 1988, 27 (08) :2846-2853

[84] Montelukast for treating seasonal allergic rhinitis: a randomized, double-blind, placebo-controlled trial performed in the spring [J].

Philip, G ;

Malmstrom, K ;

Hampel, FC ;

Weinstein, SF ;

LaForce, CF ;

Ratner, PH ;

Malice, MP ;

Reiss, TF .

CLINICAL AND EXPERIMENTAL ALLERGY, 2002, 32 (07) :1020-1028

[85] A randomized, double-blind, placebo-controlled trial of the effect of zafirlukast on upper and lower respiratory responses to cat challenge [J].

Phipatanakul, W ;

Eggleston, PA ;

Conover-Walker, MK ;

Kesavanathan, J ;

Sweitzer, D ;

Wood, RA .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2000, 105 (04) :704-710

[86] Montelukast improves asthma control in asthmatic children maintained on inhaled corticosteroids [J].

Phipatanakul, W ;

Greene, C ;

Downes, SJ ;

Cronin, B ;

Eller, TJ ;

Schneider, LC ;

Irani, AM .

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2003, 91 (01) :49-54

[87] The efficacy of montelukast in the treatment of cat allergen-induced asthma in children [J].

Phipatanakul, W ;

Nowak-Wegrzyn, A ;

Eggleston, PA ;

Van Natta, M ;

Kesavan, J ;

Schuberth, K ;

Wood, RA .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2002, 109 (05) :794-799

[88] Effects of zafirlukast on bronchial asthma and allergic rhinitis [J].

Piatti, G ;

Ceriotti, L ;

Cavallaro, G ;

Ambrosetti, U ;

Mantovani, M ;

Pistone, A ;

Centanni, S .

PHARMACOLOGICAL RESEARCH, 2003, 47 (06) :541-547

[89] Montelukast reduces airway eosinophilic inflammation in asthma: a randomized, controlled trial [J].

Pizzichini, E ;

Leff, JA ;

Reiss, TF ;

Hendeles, L ;

Boulet, LP ;

Wei, LX ;

Efthimiadis, AE ;

Zhang, J ;

Hargreave, FE .

EUROPEAN RESPIRATORY JOURNAL, 1999, 14 (01) :12-18

[90] Randomised controlled trial of montelukast plus inhaled budesonide versus double dose inhaled budesonide in adult patients with asthma [J].

Price, DB ;

Hernandez, D ;

Magyar, P ;

Fiterman, J ;

Beeh, KM ;

James, IG ;

Konstantopoulos, S ;

Rojas, R ;

van Noord, JA ;

Pons, M ;

Gilles, L ;

Leff, JA .

THORAX, 2003, 58 (03) :211-216

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