Cysteinyl leukotrienes in allergic inflammation - Strategic target for therapy

被引：110

作者：

Busse, W

Kraft, M

机构：

[1] Univ Wisconsin, Sch Med, Dept Med, Madison, WI 53792 USA

[2] Natl Jewish Med & Res Ctr, Denver, CO USA

来源：

CHEST | 2005年 / 127卷 / 04期

关键词：

asthma; cytokines; eosinophils; inflammation; leukotrienes; leukotriene receptor antagonists; remodeling; rhinitis;

D O I：

10.1378/chest.127.4.1312

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Systemically bioavailable leukotriene receptor antagonists (LTRAs) can reduce the essential components of allergic inflammation in allergic rhinitis (AR) and asthma by blocking cysteinyl leukotriene (CysLT) activity, resulting in a wide range of clinical effects. CysLTs, mediators, and modulators in the pathophysiology of asthma and AR are a key target for therapy because they modulate production of hemopoietic progenitor cells, survival and recruitment of eosinophils to inflamed tissue, activity of cytokines and chemokines, quantity of exhaled NO, smooth-muscle contraction, and proliferation of fibroblasts. The mechanism of action of LTRAs leads to their effects on systemic allergic inflammatory processes.

引用

收藏

页码：1312 / 1326

页数：15

相关论文

共 115 条

[61] Oral montelukast, inhaled beclomethasone, and placebo for chronic asthma -: A randomized, controlled trial [J].

Malmstrom, K ;

Rodriguez-Gomez, G ;

Guerra, J ;

Villaran, C ;

Piñeiro, A ;

Wei, LX ;

Seidenberg, BC ;

Reiss, TF .

ANNALS OF INTERNAL MEDICINE, 1999, 130 (06) :487-+

[62] Oral montelukast versus inhaled beclomethasone in 6-to 11-year-old children with asthma:: Results of an open-label extension study evaluating long-term safety, satisfaction, and adherence with therapy [J].

Maspero, JF ;

Dueñas-Meza, E ;

Volovitz, B ;

Daza, CP ;

Kosa, L ;

Vrijens, F ;

Leff, JA .

CURRENT MEDICAL RESEARCH AND OPINION, 2001, 17 (02) :96-104

[63] Effects of cysteinyl leukotrienes in small human bronchus and antagonist activity of montelukast and its metabolites [J].

Mechiche, H ;

Naline, E ;

Candenas, L ;

Pinto, FM ;

Birembault, P ;

Advenier, C ;

Devillier, P .

CLINICAL AND EXPERIMENTAL ALLERGY, 2003, 33 (07) :887-894

[64] Cysteinyl leukotrienes and uridine diphosphate induce cytokine generation by human mast cells through an interleukin 4-regulated pathway that is inhibited by leukotriene receptor antagonists [J].

Mellor, EA ;

Austen, KF ;

Boyce, JA .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (05) :583-592

[65] Cysteinyl leukotriene receptor 1 is also a pyrimidinergic receptor and is expressed by human mast cells [J].

Mellor, EA ;

Maekawa, A ;

Austen, KF ;

Boyce, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (14) :7964-7969

[66] BEHAVIOR AND CLINICAL RELEVANCE OF HISTAMINE AND LEUKOTRIENE-C4 AND LEUKOTRIENE-B4 IN GRASS POLLEN-INDUCED RHINITIS [J].

MIADONNA, A ;

TEDESCHI, A ;

LEGGIERI, E ;

LORINI, M ;

FOLCO, G ;

SALA, A ;

QUALIZZA, R ;

FROLDI, M ;

ZANUSSI, C .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1987, 136 (02) :357-362

[67] ALLERGIC AND NON-ALLERGIC RHINITIS - THEIR CHARACTERIZATION WITH ATTENTION TO THE MEANING OF NASAL EOSINOPHILIA [J].

MULLARKEY, MF ;

HILL, JS ;

WEBB, DR .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1980, 65 (02) :122-126

[68] Clinical manifestations of the release of histamine and other inflammatory mediators [J].

Naclerio, R .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1999, 103 (03) :S382-S385

[69] The effects of IL-5 on airway physiology and inflammation in rats [J].

Nag, SS ;

Xu, LJ ;

Hamid, Q ;

Renzi, PM .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2003, 111 (03) :558-566

[70] Leukotriene D4 upregulates eosinophil adhesion via the cysteinyl leukotriene 1 receptor [J].

Nagata, M ;

Saito, K ;

Tsuchiya, K ;

Sakamoto, Y .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2002, 109 (04) :676-680

← 2 3 4 5 6 7 8 9 10 11 →