Possibility of application of quaternary chitosan having pendant galactose residues as gene delivery tool

被引：90

作者：

Murata, J

Ohya, Y

Ouchi, T

机构：

[1] Department of Applied Chemistry, Faculty of Engineering, Kansai University, Suita

来源：

CARBOHYDRATE POLYMERS | 1996年 / 29卷 / 01期

关键词：

D O I：

10.1016/0144-8617(95)00144-1

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Since chitosan is a cationic natural polysaccharide having the formation ability of a polyelectrolyte complex with DNA, it is expected to be used as a carrier of DNA in gene delivery systems. So, in order to achieve an efficient gene delivery via receptor-mediated endocytosis, the synthesis of a novel polycationic polysaccharide derivative having recognizable saccharide residues, N,N,N-trimethyl(TM)-chitosan/galactose conjugate, was performed. The formation of a polyelectrolyte complex with DNA and the cellular recognition ability of TM-chitosan/galactose conjugate were tested, and then the possibility of its application as a gene delivery tool was investigated. Copyright (C) 1996 Elsevier Science Ltd

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页码：69 / 74

页数：6

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