Vinculin, an adapter protein in control of cell adhesion signalling

被引：217

作者：

Carisey, Alex ^{[1
]}

Ballestrem, Christoph ^{[1
]}

机构：

[1] Univ Manchester, Fac Life Sci, Wellcome Trust Ctr Cell Matrix Res, Manchester M13 9PT, Lancs, England

来源：

EUROPEAN JOURNAL OF CELL BIOLOGY | 2011年 / 90卷 / 2-3期

基金：

英国生物技术与生命科学研究理事会;

关键词：

Cell migration; Focal adhesion; Vinculin; Actin; Cell adhesion; Cell proliferation; Mechanical force; F-ACTIN-BINDING; FOCAL ADHESIONS; ALPHA-CATENIN; INTRAMOLECULAR ASSOCIATION; CYTOSKELETAL ORGANIZATION; TYROSINE PHOSPHORYLATION; MICROFILAMENT BUNDLES; JUNCTIONAL COMPLEX; ADHERENS JUNCTIONS; ACTIVATE VINCULIN;

D O I：

10.1016/j.ejcb.2010.06.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Vinculin, discovered in 1979 (Geiger, 1979), is an adapter protein with binding sites for more than 15 proteins. Biochemical and structural analyses have contributed to detailed knowledge about potential binding partners and the understanding of how their binding may be regulated. Despite all this information the molecular basis of how vinculin acts in cells and controls a wide variety of signals remains elusive. This review aims to highlight recent discoveries with an emphasis on how vinculin is involved in the coordination of a network of signals. (C) 2010 Elsevier GmbH. All rights reserved.

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收藏

页码：157 / 163

页数：7

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