Effect of leg rotation on hip bone mineral density measurements

Bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA) is widely used in the management of patients with osteoporosis. Factors, which are specific to machine or to operator, can influence the accuracy and precision of BMD estimations. We studied the effect of leg rotation by 10degrees either internally or externally from the standard position in a group of 50 women (average age 54.9, SD = 11.1 yr) who were free of bone active diseases or medications. External rotation of leg by 10degrees from the customary position increased the average BNID by 0.005, 0.003, and 0.036 g/cm(2) in the femoral neck, trochanter, and Ward's area (p = 0.119, 0.309, and <0.001), respectively. Internal rotation of leg by 10degrees from the customary position decreased the average BNID by 0.009, 0.005, and 0.006 g/cm(2) in the femoral neck, trochanter, and Ward's area (p = <0.0011 0.008, and <0.001), respectively. The number of subjects qualified for the diagnosis of osteoporosis based on the T-scores (equal to or below -2.5) of the femoral neck and trochanter did not change significantly in three different positions (18% in the customary position and after the external rotation and 14% after the internal rotation). A significant change in the femoral neck BMD (defined as 2.77 x precision error) was seen in 12% of subjects after the internal rotation and 8% after the external rotation. Our data emphasize the need for proper positioning of the hip during DXA scanning. Malrotation of the hip can be an important confounding factor when interpreting serial BMD values.