A glucose-sensing polymer

被引：114

作者：

Chen, GH ^{[1
]}

Guan, ZB ^{[1
]}

Chen, CT ^{[1
]}

Fu, LT ^{[1
]}

Sundaresan, V ^{[1
]}

Arnold, FH ^{[1
]}

机构：

[1] CALTECH,DIV CHEM & CHEM ENGN 21041,PASADENA,CA 91125

来源：

NATURE BIOTECHNOLOGY | 1997年 / 15卷 / 04期

关键词：

diabetes mellitus; biosensor; copper-triazacyclononane; molecular imprinting;

D O I：

10.1038/nbt0497-354

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have prepared a robust polymer that can be used to measure glucose concentrations in complex biological media. At alkaline pH, the metal-complexing polymer binds glucose and instantly releases protons in proportion to the glucose concentration over a clinically relevant range (0 to 25 mM). The inexpensive polymer is sufficiently selective to provide an easily measurable response to glucose in porcine plasma. The polymer's ability to function at nonphysiological pH (at which the buffer capacity of biological samples is small) makes it possible to design simple and inexpensive sensing devices based on measurement of changes in proton concentration.

引用

页码：354 / 357

页数：4

共 13 条

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