Relationship between increased longevity and stress resistance as assessed through gerontogene mutations in Caenorhabditis elegans

被引：126

作者：

Johnson, TE ^{[1
]}

de Castro, E ^{[1
]}

de Castro, SH ^{[1
]}

Cypser, J ^{[1
]}

Henderson, S ^{[1
]}

Tedesco, P ^{[1
]}

机构：

[1] Univ Colorado, Inst Behav Genet, Boulder, CO 80309 USA

来源：

EXPERIMENTAL GERONTOLOGY | 2001年 / 36卷 / 10期

关键词：

aging mutants; longevity; senescence; stress resistance; genetic pathways; molecular genetics; reactive oxidants; thermotolerance; oxidative stress;

D O I：

10.1016/S0531-5565(01)00144-9

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

We review the status of the hypothesis that interventions that increase the resistance to stress offer the potential for effective life prolongation and increased health. The work focuses on research in the nematode worm Caenorhabditis elegans and describes both published and unpublished results consistent with this hypothesis. Correlations between stress resistance and longevity among many gerontogene mutants is provided. (C) 2001 Elsevier Science Inc. All rights reserved.

引用

页码：1609 / 1617

页数：9

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