Porins: General to specific, native to engineered passive pores

被引：106

作者：

Schulz, GE

机构：

[1] Inst. fur Org. Chem. und Biochem., Albert-Ludwigs-Universität, D-79104, Freiburg im Breisgau

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1996年 / 6卷 / 04期

关键词：

D O I：

10.1016/S0959-440X(96)80113-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several porins from bacterial outer membranes have been crystallized and analyzed by X-ray diffraction, yielding a consistent picture of these membrane-channel proteins. The structures of general and specific channels are in agreement with electrophysiological, diffusional and biochemical data, and provide a starting point for the engineering of other passive membrane pores or porins with new selectivities.

引用

收藏

页码：485 / 490

页数：6

相关论文

共 61 条

[11] CADAVERINE INDUCES CLOSING OF ESCHERICHIA-COLI PORINS [J].

DELAVEGA, AL ;

DELCOUR, AH .

EMBO JOURNAL, 1995, 14 (23) :6058-6065

[12] Crystal structures of various maltooligosaccharides bound to maltoporin reveal a specific sugar translocation pathway [J].

Dutzler, R ;

Wang, YF ;

Rizkallah, PJ ;

Rosenbusch, JP ;

Schirmer, T .

STRUCTURE, 1996, 4 (02) :127-134

[13]

EISELE JL, 1990, J BIOL CHEM, V265, P10217

[14] THE PROPERTIES OF ION CHANNELS FORMED BY THE COUMARIN ANTIBIOTIC, NOVOBIOCIN, IN LIPID BILAYERS [J].

FEIGIN, AM ;

ARONOV, EV ;

TEETER, JH ;

BRAND, JG .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1995, 1234 (01) :43-51

[15] CRYSTALLIZATION AND PRELIMINARY-X-RAY DIFFRACTION ANALYSIS OF SCRY, A SPECIFIC BACTERIAL OUTER-MEMBRANE PORIN [J].

FORST, D ;

SCHULEIN, K ;

WACKER, T ;

DIEDERICHS, K ;

KREUTZ, W ;

BENZ, R ;

WELTE, W .

JOURNAL OF MOLECULAR BIOLOGY, 1993, 229 (01) :258-262

[16] ARTIFICIAL TRANSMEMBRANE ION CHANNELS FROM SELF-ASSEMBLING PEPTIDE NANOTUBES [J].

GHADIRI, MR ;

GRANJA, JR ;

BUEHLER, LK .

NATURE, 1994, 369 (6478) :301-304

[17] MOLECULAR DESIGN OF THE VOLTAGE-DEPENDENT, ANION-SELECTIVE CHANNEL IN THE MITOCHONDRIAL OUTER-MEMBRANE [J].

GUO, XW ;

SMITH, PR ;

MANNELLA, CA .

JOURNAL OF STRUCTURAL BIOLOGY, 1995, 114 (01) :41-59

[18] FORCES AND FACTORS THAT CONTRIBUTE TO THE STRUCTURAL STABILITY OF MEMBRANE-PROTEINS [J].

HALTIA, T ;

FREIRE, E .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 1995, 1228 (01) :1-27

[19] ANTIMICROBIAL PEPTIDE PORES IN MEMBRANES DETECTED BY NEUTRON INPLANE SCATTERING [J].

HE, K ;

LUDTKE, SJ ;

HUANG, HW ;

WORCESTER, DL .

BIOCHEMISTRY, 1995, 34 (48) :15614-15618

[20]

HEINS L, 1994, J BIOL CHEM, V269, P26402

← 1 2 3 4 5 6 7 →