Porins: General to specific, native to engineered passive pores

被引：106

作者：

Schulz, GE

机构：

[1] Inst. fur Org. Chem. und Biochem., Albert-Ludwigs-Universität, D-79104, Freiburg im Breisgau

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1996年 / 6卷 / 04期

关键词：

D O I：

10.1016/S0959-440X(96)80113-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several porins from bacterial outer membranes have been crystallized and analyzed by X-ray diffraction, yielding a consistent picture of these membrane-channel proteins. The structures of general and specific channels are in agreement with electrophysiological, diffusional and biochemical data, and provide a starting point for the engineering of other passive membrane pores or porins with new selectivities.

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页码：485 / 490

页数：6

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