Electrospun P(LLA-CL) nanofiber: a biomimetic extracellular matrix for smooth muscle cell and endothelial cell proliferation

被引：686

作者：

Mo, XM

Xu, CY

Kotaki, M

Ramakrishna, S

机构：

[1] Natl Univ Singapore, Dept Mech Engn, Singapore 117576, Singapore

[2] Natl Univ Singapore, Div Bioengn, Singapore 117576, Singapore

来源：

BIOMATERIALS | 2004年 / 25卷 / 10期

关键词：

electrospinning; nanofiber; scaffold; smooth muscle cell; endothelial cell; poly(L-lactide-co-epsilon-caprolactone);

D O I：

10.1016/j.biomaterials.2003.08.042

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Poly(L-lactide-co-epsilon-caprolactone) [P(LLA-CL)] with L-lactide to epsilon-caprolactone ratio of 75 to 25 has been electrospun into nanofibers. The relationship between electrospinning parameters and fiber diameter has been investigated. The fiber diameter decreased with decreasing polymer concentration and with increasing electrospinning voltage. The X-ray diffractometer and differential scanning colorimeter results suggested that the electrospun nanofibers developed highly oriented structure in CL-unit sequences during the electrospinning process. The biocompatibility of the nanofiber scaffold has been investigated by culturing cells on the nanofiber scaffold. Both smooth muscle cell and endothelial cell adhered and proliferated well on the P(LLA-CL) nanofiber scaffolds. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：1883 / 1890

页数：8

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