Roles of p38 MAPKs in invasion and metastasis

被引：121

作者：

Barrantes, Ivan del Barco ^{[1
]}

Nebreda, Angel R. ^{[1
,2
]}

机构：

[1] Inst Res Biomed IRB Barcelona, Barcelona 08028, Spain

[2] ICREA, Barcelona, Spain

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2012年 / 40卷

关键词：

cancer; metastasis; p38 mitogen-activated protein kinase (p38 MAPK); tumour cell; ACTIVATED PROTEIN-KINASE; BREAST-CANCER CELLS; CARCINOMA-CELLS; ENDOTHELIAL-CELLS; TGF-BETA; TRANSENDOTHELIAL MIGRATION; MESENCHYMAL TRANSITION; PROMOTES INVASION; TUMOR-SUPPRESSOR; LUNG METASTASIS;

D O I：

10.1042/BST20110676

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cells from primary tumours need to go through several steps to become fully metastatic. During this process, cancer cells acquire the ability to invade, migrate across the surrounding tissue, enter into the circulation and colonize distant organs. In the present paper, we review recent progress in understanding how the p38 MAPK (mitogen-activated protein kinase) signalling pathway participates in the different steps of metastasis. Experimental evidence suggests that tumour cells need to modulate p38 MAPK activity levels to successfully metastasize.

引用

页码：79 / 84

页数：6

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