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Telithromycin in lower respiratory tract infections

被引：5
作者：
Blasi, F.
Cazzola, M.
Tarsia, P.
Aliberti, S.
Baldessari, C.
Valenti, V.
机构：
[1] Univ Milan, Osped Maggiore, IRCCS, Inst Resp Dis, I-20122 Milan, Italy
[2] Carderelli Hosp, Dept Resp Med, Unit Pneumol & Allergol, Naples, Italy
来源：
FUTURE MICROBIOLOGY | 2006年 / 1卷 / 01期
关键词：
acute exacerbations of chronic bronchitis; asthma; community-acquired pneumonia; telithromycin;
D O I：
10.2217/17460913.1.1.7
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Telithromycin is a ketolide, a semisynthetic derivative of the 14-membered ring macrolide antibiotics, with an expanded spectrum of activity relative to macrolides. Its good tissue pharmacokinetic characteristics allows once-daily administration, and it has been successfully employed in lower respiratory tract infections. Recent data indicate that telithromycin may exert anti-inflammatory/immunomodulatory effects that may be of use in the treatment of both acute and chronic airway diseases. This review examines the role of telithromycin in lower respiratory tract infections, analyzing published data on exacerbations of chronic bronchitis, community-acquired pneumonia and asthma in adults. In addition, pharmacokinetic and pharmacodynamic properties of the drug are considered.
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页码：7 / 16
页数：10
相关论文
共 61 条
  • [11] CAZZOLA M, 2004, EUR RESP MON, V28, P13
  • [12] Brief communication: Severe hepatotoxicity of telithromycin: Three case reports and literature review
    Clay, KD
    Hanson, JS
    Pope, SD
    Rissmiller, RW
    Purclum, PP
    Banks, PM
    [J]. ANNALS OF INTERNAL MEDICINE, 2006, 144 (06) : 415 - 420
  • [13] Douthwaite S, 2001, J ANTIMICROB CHEMOTH, V48, P1
  • [14] Efficacy and tolerability of once-daily oral telithromycin compared with clarithromycin for the treatment of community-acquired pneumonia in adults
    Dunbar, LM
    Hassman, J
    Tellier, G
    [J]. CLINICAL THERAPEUTICS, 2004, 26 (01) : 48 - 62
  • [15] Roxithromycin, clarithromycin, and azithromycin attenuate the injurious effects of bioactive phospholipids on human respiratory epithelium in vitro
    Feldman, C
    Anderson, R
    Theron, AJ
    Ramafi, G
    Cole, PJ
    Wilson, R
    [J]. INFLAMMATION, 1997, 21 (06) : 655 - 665
  • [16] The effects of ketolides on bioactive phospholipid-induced injury to human respiratory epithelium in vitro
    Feldman, C
    Anderson, R
    Theron, A
    Mokgobu, I
    Cole, PJ
    Wilson, R
    [J]. EUROPEAN RESPIRATORY JOURNAL, 1999, 13 (05) : 1022 - 1028
  • [17] Five-day telithromycin once daily is as effective as 10-day clarithromycin twice daily for the treatment of acute exacerbations of chronic bronchitis and is associated with reduced health-care resource utilization
    Fogarty, C
    de Wet, R
    Mandell, L
    Chang, J
    Rangaraju, M
    Nusrat, R
    [J]. CHEST, 2005, 128 (04) : 1980 - 1988
  • [18] Telithromycin for the treatment of acute exacerbations of chronic bronchitis
    Fogarty, C
    Zervos, M
    Tellier, G
    Aubier, M
    Rangaraju, M
    Nusrat, R
    [J]. INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 2005, 59 (03) : 296 - 305
  • [19] Efficacy and safety of telithromycin 800 mg once daily for 7 days in community-acquired pneumonia: an open-label, multicenter study
    Fogarty, CM
    Patel, TC
    Dunbar, LM
    Leroy, BP
    [J]. BMC INFECTIOUS DISEASES, 2005, 5 (1)
  • [20] Telithromycin in the treatment of pneumococcal community-acquired respiratory tract infections: a review
    Fogarty, CM
    Buchanan, P
    Aubier, M
    Baz, M
    van Rensburg, D
    Rangaraju, M
    Nusrat, R
    [J]. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2006, 10 (02) : 136 - 147
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