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Telithromycin in lower respiratory tract infections

被引：5
作者：
Blasi, F.
Cazzola, M.
Tarsia, P.
Aliberti, S.
Baldessari, C.
Valenti, V.
机构：
[1] Univ Milan, Osped Maggiore, IRCCS, Inst Resp Dis, I-20122 Milan, Italy
[2] Carderelli Hosp, Dept Resp Med, Unit Pneumol & Allergol, Naples, Italy
来源：
FUTURE MICROBIOLOGY | 2006年 / 1卷 / 01期
关键词：
acute exacerbations of chronic bronchitis; asthma; community-acquired pneumonia; telithromycin;
D O I：
10.2217/17460913.1.1.7
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Telithromycin is a ketolide, a semisynthetic derivative of the 14-membered ring macrolide antibiotics, with an expanded spectrum of activity relative to macrolides. Its good tissue pharmacokinetic characteristics allows once-daily administration, and it has been successfully employed in lower respiratory tract infections. Recent data indicate that telithromycin may exert anti-inflammatory/immunomodulatory effects that may be of use in the treatment of both acute and chronic airway diseases. This review examines the role of telithromycin in lower respiratory tract infections, analyzing published data on exacerbations of chronic bronchitis, community-acquired pneumonia and asthma in adults. In addition, pharmacokinetic and pharmacodynamic properties of the drug are considered.
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页码：7 / 16
页数：10
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