Solid phase synthesis of carbocyclic L-2′-deoxynucleosides

被引：20

作者：

Choo, H ^{[1
]}

Chong, YH ^{[1
]}

Chu, CK ^{[1
]}

机构：

[1] Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 10期

关键词：

D O I：

10.1021/ol015783n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Carbocyclic L-2 ' deoxynucleosides 17 were synthesized on solid phase in four steps from the appropriately protected intermedate 11, The Mitsunobu reaction was used as a condensation method between the carbocyclic moiety and heterocyclic bases. The regioselectivity of the carbocyclic nucleosides was compared between the solid and solution phase syntheses.

引用

页码：1471 / 1473

页数：3

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