Obstetric outcome of in vitro fertilized pregnancies complicated by severe ovarian hyperstimulation syndrome: a multicenter study

被引:87
作者
Abramov, Y [1 ]
Elchalal, U [1 ]
Schenker, JG [1 ]
机构
[1] Hebrew Univ Jerusalem, Hadassah Med Ctr, Dept Obstet & Gynecol, IL-91120 Jerusalem, Israel
关键词
IVF; ovarian hyperstimulation syndrome; pregnancy outcome;
D O I
10.1016/S0015-0282(98)00350-1
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To assess the outcome of pregnancies conceived with the use of IVF that are complicated by severe ovarian hyperstimulation syndrome (OHSS). Design: A retrospective nationwide multicenter study. Setting: Sixteen of 19 tertiary care medical centers in Israel. Patient(s): All patients undergoing IVF who were hospitalized for severe OHSS between January 1987 and December 1996. Main Outcome Measure(s): Pregnancy rate (PR) and rates of multiple gestation, miscarriage, ectopic pregnancy, obstetric complications, and intervention. Result(s): A total of 163 patients who had severe OHSS after IVF treatment were identified, of whom 142 (87.1%) had undergone ET. The clinical PR was 73.2%; 42.3% were singletons, 33.6% were twins, 17.3% were triplets, and 6.7% were quadruplets. The miscarriage rate was 29.8%, whereas the incidence of ectopic pregnancy was 1.9%. Forty-four percent of all births were premature, and 62.1% of all newborns had low birth weight. The most common antenatal complications were pregnancy-induced hypertension (13.2%), gestational diabetes (5.9%), and placental abruption (4.4%). The rate of cesarean section was 44.1%. Conclusion(s): Among patients who have severe OHSS after IVF treatment, the pregnancy rate and the rates of multiple gestation, miscarriage,prematurity, low birth weight, pregnancy-induced hypertension, gestational diabetes, and placental abruption are significantly higher than those reported previously for pregnancies conceived with the use of assisted reproductive techniques. (Fertil Steril(R) 1998;70:1070-6. (C) 1998 by American Society for Reproductive Medicine.)
引用
收藏
页码:1070 / 1076
页数:7
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