Nobiletin metabolites: Synthesis and inhibitory activity against matrix metalloproteinase-9 production

被引：35

作者：

Oshitari, Tetsuta ^{[1
]}

Okuyama, Yuji ^{[1
]}

Miyata, Yoshiki ^{[1
]}

Kosano, Hiroshi ^{[1
]}

Takahashi, Hideyo ^{[1
]}

Natsugari, Hideaki ^{[1
]}

机构：

[1] Teikyo Univ, Sch Pharmaceut Sci, Midori Ku, Kanagawa 2525195, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2011年 / 21卷 / 15期

关键词：

Nobiletin; Polymethoxyflavone; Ulmann reaction; Baker-Venkataraman rearrangement; Matrix metalloproteinase-9; FIBROSARCOMA HT-1080 CELLS; MATRIX METALLOPROTEINASES; URINARY METABOLITES; CITRUS-RETICULATA; GENE-EXPRESSION; IN-VITRO; PHOSPHORYLATION; FLAVONE; MOUSE; DIFFERENTIATION;

D O I：

10.1016/j.bmcl.2011.05.121

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

A divergent synthesis of nobiletin metabolites was developed through highly oxygenated acetophenone derivative. We used commercially available methyl 3,4,5-trimethoxybenzoate as a starting material for concise preparation of the key intermediate, 2'-hydroxy-3',4',5',6'-tetramethoxyacetophenone (I). These metabolites showed strong inhibitory activity against matrix metalloproteinase-9 production in human lens epithelial cells. (C) 2011 Elsevier Ltd. All rights reserved.

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页码：4540 / 4544

页数：5

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