Gold-nanorod-based sensing of sequence specific HIV-1 virus DNA by using hyper-Rayleigh scattering spectroscopy

被引：92

作者：

Darbha, Gopala Krishna ^{[1
]}

Rai, Uma Shanker ^{[1
]}

Singh, Anant Kumar ^{[1
]}

Ray, Paresh Chandra ^{[1
]}

机构：

[1] Jackson State Univ, Dept Chem, Jackson, MS 39217 USA

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2008年 / 14卷 / 13期

关键词：

DNA; gold; human immunodeficiency virus; nanostructures; sensors;

D O I：

10.1002/chem.200701850

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Infectious diseases caused by the human immunodeficiency virus (HIV) remain the leading killers of human beings worldwide, and function to destabilize societies in Africa, Asia, and the Middle East. Driven by the need to detect the presence of HIV viral sequence, here we demonstrate that the second-order nonlinear optical (NLO) properties of gold nanorods can be used for screening HIV-1 viral DNA sequence without any modification, with good sensitivity (100 picomolar) and selectivity (single base-pair mismatch). The hyper-Rayleigh scattering (HRS) intensity increases 45 times when a label-free 145-mer, ss-gag gene DNA, was hybridized with 100 pM target DNA. The mechanism of HRS intensity change has been discussed with experimental evidence for higher multipolar contribution to the NLO response of gold nanorods.

引用

页码：3896 / 3903

页数：8

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