Identification and characterization of a zinc finger gene (ZNF213) from 16p13.3

被引：10

作者：

Chen, XG

Hamon, M

Deng, ZM

Centola, M

Sood, R

Taylor, K

Kastner, DL

Fischel-Ghodsian, N

机构：

[1] Cedars Sinai Med Ctr, Ctr Med Genet Birth Defects, Steven Spielberg Pediat Res Ctr, Ahmanson Dept Pediat, Los Angeles, CA 90048 USA

[2] Univ Calif Los Angeles, Sch Med, Los Angeles, CA 90048 USA

[3] NIAMSD, Arthrit & Rheumatism Branch, Bethesda, MD 20892 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1999年 / 1444卷 / 02期

关键词：

direct cDNA selection; Familial Mediterranean fever; zinc finger protein; gene structure and expression;

D O I：

10.1016/S0167-4781(98)00273-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

During our search for the familial Mediterranean fever (FMF) gene, we identified by cDNA selection a 1.2 kb cDNA fragment representing a novel human gene that is expressed in a wide variety of tissues. This gene spans approx. 8.0 kb genomic DNA and has seven exons. Its 3' untranslated region contains a long tandem repeat that gives rise to a polymorphism with two alleles of approx. 1.1 kb and 1.0 kb, with the 1.1 kb allele in strong linkage disequilibrium with FMF in patients of different ethnic backgrounds. However, both genetic and mutational analyses have excluded this gene as the one responsible for FMF. The predicted 424 amino acid protein, designated ZNF213, contains three C2H2 zinc fingers, a Kruppel associated A box and a leucine rich motif (LeR domain/SCAN box), strongly suggestive of a transcription factor. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：218 / 230

页数：13

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