Renin-angiotensin system gene polymorphisms: potential mechanisms for their association with cardiovascular diseases

被引:70
作者
Danser, AHJ
Schunkert, H
机构
[1] Erasmus Univ, Dept Pharmacol, NL-3015 GE Rotterdam, Netherlands
[2] Univ Regensburg, Klin & Poliklin Innere Med 2, D-8400 Regensburg, Germany
关键词
angiotensin; angiotensin-converting enzyme; angiotensinogen; angiotensin AT(1) receptor; polymorphism; renin;
D O I
10.1016/S0014-2999(00)00823-2
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Since the first description of the angiotensin-converting enzyme insertion/deletion polymorphism more than a decade ago, many hundreds of investigations have reported associations between this polymorphism and cardiovascular diseases. Subsequently, similar studies were performed in relationship with several other renin-angiotensin system gene polymorphisms, most notably the angiotensinogen M235T polymorphism and the angiotensin AT, receptor A1166C polymorphism. Surprisingly however, especially in view of the many contradictory results that have been obtained, very little attention has been paid to the mechanism(s) that may link these genetic variants and respective diseases. Here, we review the limited evidence that is currently available on the functional consequences (including compensatory mechanisms) of the above three renin-angiotensin system gene polymorphisms, in order to provide an explanation for the reported associations (or lack thereof) between these polymorphisms and cardiovascular diseases. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:303 / 316
页数:14
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