PEG-polymer-supported liquid-phase combinatorial synthesis of structurally diverse 2,3-dihydro-4-pyridones

被引：10

作者：

Guo, HC ^{[1
]}

Wang, Z ^{[1
]}

Ding, KL ^{[1
]}

机构：

[1] Shanghai Med Univ, Shanghai Inst Organ Chem, State Key Lab Organomet Chem, Shanghai 200032, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2005年 / 07期

关键词：

PEG; liquid-phase synthesis; combinatorial; aza Diels-Alder reactions; 2,3-dihydro-4-pyridones;

D O I：

10.1055/s-2005-861857

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient liquid-phase synthetic protocol for the construction of structurally diverse 2,3-dihydro-4-pyridones on soluble polymer support by the aza Diels-Alder reaction has been developed, which utilized a one-pot three-component reaction of either PEG-supported amine, aromatic aldehydes and the Danishefsky's diene, or PEG-supported aldehyde, aromatic amines and Danishefsky's diene.

引用

页码：1061 / 1068

页数：8

共 69 条

[1]

Akiyama T, 2002, SYNLETT, P1898

[2] Bronsted acid-catalyzed aza Diels-Alder reaction of Danishefsky's diene with aldimine generated in situ from aldehyde and amine in aqueous media [J].

Akiyama, T ;

Takaya, J ;

Kagoshima, H .

TETRAHEDRON LETTERS, 1999, 40 (44) :7831-7834

[3] Indium triflate - An efficient catalyst for hetero Diels-Alder reactions [J].

Ali, T ;

Chauhan, KK ;

Frost, CG .

TETRAHEDRON LETTERS, 1999, 40 (30) :5621-5624

[4]

Balkenhohl F, 1996, ANGEW CHEM INT EDIT, V35, P2289

[5] Rapid microwave-assisted liquid-phase combinatorial synthesis of 2-(arylamino)benzimidazoles [J].

Bendale, PM ;

Sun, CM .

JOURNAL OF COMBINATORIAL CHEMISTRY, 2002, 4 (04) :359-361

[6]

Bennett WD, 2000, PRACT APPROACH SER, V233, P139

[7] Traceless solid-phase organic synthesis [J].

Blaney, P ;

Grigg, R ;

Sridharan, V .

CHEMICAL REVIEWS, 2002, 102 (07) :2607-2624

[8] Formats for combinatorial synthesis: solid-phase, liquid-phase and surface [J].

Boyle, NA ;

Janda, KD .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2002, 6 (03) :339-346

[9] Recent developments in imino Diels-Alder reactions [J].

Buonora, P ;

Olsen, JC ;

Oh, T .

TETRAHEDRON, 2001, 57 (29) :6099-6138

[10]

Carruthers W, 1990, Cycloaddition Reactions in Organic Synthesis

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