A new strategy for the elaboration of pyrrolidine N-oxides using the reverse-Cope elimination

被引：14

作者：

Hanrahan, JR ^{[1
]}

Knight, DW ^{[1
]}

机构：

[1] Cardiff Univ, Dept Chem, Cardiff CF1 3TB, S Glam, Wales

来源：

CHEMICAL COMMUNICATIONS | 1998年 / 20期

关键词：

D O I：

10.1039/a806335d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Condensations of the unsaturated nitrones 13 with lithiated methyl phenyl sulfone provide excellent yields of the unsaturated hydroxylamines 14 as single stereoisomers, which undergo rapid reverse-Cope elimination at ambient temperature, assisted by the constraint of the acetonide ring, leading to the pyrrolidine N-oxides 15 as single enantiomers.

引用

页码：2231 / 2232

页数：2

共 14 条

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