High-performance liquid chromatography-electrospray ionization mass spectrometry and multiple mass spectrometry studies of hyperforin degradation products

被引：43

作者：

Fuzzati, N ^{[1
]}

Gabetta, B ^{[1
]}

Strepponi, I ^{[1
]}

Villa, F ^{[1
]}

机构：

[1] Indena SpA, Lab Ric & Sviluppo, I-20090 Milan, Italy

来源：

JOURNAL OF CHROMATOGRAPHY A | 2001年 / 926卷 / 01期

关键词：

Hypericum perforatum; hyperforin; adhyperforin; furohyperforin; phloroglucinols;

D O I：

10.1016/S0021-9673(01)01000-7

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The alcoholic extract of the aerial parts of Hypericum perforatum L. finds wide application because of its antidepressant activity. The extract contains a number of constituents with documented biological activity including chlorogenic acid, a broad range of flavonoids, naphthodianthrones and phloroglucinols. Hyperforin and adhyperforin are the major phloroglucinol constituents found in the lipophilic fraction of the extracts. Since the stability of hyperforin has been shown to be limited, an investigation of the hyperforin degradation products using HPLC-electrospray ionization mass spectrometry and multiple mass spectrometry was undertaken. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：187 / 198

页数：12

共 11 条

[1]

Bombardelli Ezio, 1995, Fitoterapia, V66, P43

[2] Identification by high-performance liquid chromatography diode array detection mass spectrometry and quantification by high-performance liquid chromatography UV absorbance detection of active constituents of Hypericum perforatum [J].