Synthesis of piperazinones and benzopiperazinones from 1,2-diamines and organoboronic acids

被引：73

作者：

Petasis, NA ^{[1
]}

Patel, ZD

机构：

[1] Univ So Calif, Dept Chem, Los Angeles, CA 90089 USA

[2] Univ So Calif, Loker Hydrocarbon Res Inst, Los Angeles, CA 90089 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 49期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(00)01717-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Alkenyl, aryl and heteroaryl boronic acids react with 1,2-diamines and glyoxylic acid to give directly in one step the corresponding piperazinones (2-oxopiperazines). Similarly, the use of monoprotected 1,2-phenylenediamine leads to benzopiperazinones( 1,2,3,4-tetrahydroquinoxalin-2-ones). (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：9607 / 9611

页数：5

共 24 条

[21] Synthesis of a constrained enkephalin analog to illustrate a novel route to the piperazinone ring structure
Shreder, K
Zhang, L
Goodman, M
[J]. TETRAHEDRON LETTERS, 1998, 39 (3-4) : 221 - 224
[22] Conformationally constrained substance P analogues:: The total synthesis of a constrained peptidomimetic for the Phe7-Phe8 region
Tong, YS
Fobian, YM
Wu, MY
Boyd, ND
Moeller, KD
[J]. JOURNAL OF ORGANIC CHEMISTRY, 2000, 65 (08) : 2484 - 2493
[23] Efficient synthesis of N-arylpiperazinones via a selective intramolecular Mitsunobu cyclodehydration
Weissman, SA
Lewis, S
Askin, D
Volante, RP
Reider, PJ
[J]. TETRAHEDRON LETTERS, 1998, 39 (41) : 7459 - 7462
[24] Solid-phase synthesis of substituted 4-acyl-1,2,3,4-tetrahydroquinoxalin-2-ones
Zaragoza, F
Stephensen, H
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1999, 64 (07) : 2555 - 2557

← 1 2 3 →