Beyond kinetic traps in RNA folding

被引：163

作者：

Treiber, DK

Williamson, JR

机构：

[1] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2001年 / 11卷 / 03期

关键词：

D O I：

10.1016/S0959-440X(00)00206-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Large RNAs often have rugged folding energy landscapes that result in severe misfolding and slow folding kinetics, Several interdependent parameters that contribute to misfolding are now well understood and examples of targe RNAs and ribonucleoproteins that avoid kinetic traps have been reported. These advances have facilitated the exploration of fundamental RNA folding processes that were previously inaccessible.

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页码：309 / 314

页数：6

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共 42 条

[1] Structure of the S15,S18-rRNA complex: Assembly of the 30S ribosome central domain [J].

Agalarov, SC ;

Prasad, GS ;

Funke, PM ;

Stout, CD ;

Williamson, JR .

SCIENCE, 2000, 288 (5463) :107-112

[2] The complete atomic structure of the large ribosomal subunit at 2.4 Å resolution [J].

Ban, N ;

Nissen, P ;

Hansen, J ;

Moore, PB ;

Steitz, TA .

SCIENCE, 2000, 289 (5481) :905-920

[3] The parallel universe of RNA folding [J].

Batey, RT ;

Doudna, JA .

NATURE STRUCTURAL BIOLOGY, 1998, 5 (05) :337-340

[4] Effects of polyvalent cations on the folding of an rRNA three-way junction and binding of ribosomal protein S15 [J].

Batey, RT ;

Williamson, JR .

RNA, 1998, 4 (08) :984-997

[5] A magnesium ion core at the heart of a ribozyme domain [J].

Cate, JH ;

Hanna, RL ;

Doudna, JA .

NATURE STRUCTURAL BIOLOGY, 1997, 4 (07) :553-558

[6] Studies of RNA cleavage by photolysis of N-hydroxypyridine-2(1H)-thione.: A new photochemical footprinting method [J].

Chaulk, SG ;

Pezacki, JP ;

MacMillan, AM .

BIOCHEMISTRY, 2000, 39 (34) :10448-10453

[7] Assaying RNA chaperone activity in vivo using a novel RNA folding trap [J].

Clodi, E ;

Semrad, K ;

Schroeder, R .

EMBO JOURNAL, 1999, 18 (13) :3776-3782

[8] ESCHERICHIA-COLI PROTEINS, INCLUDING RIBOSOMAL-PROTEIN S12, FACILITATE IN-VITRO SPLICING OF PHAGE-T4 INTRONS BY ACTING AS RNA CHAPERONES [J].

COETZEE, T ;

HERSCHLAG, D ;

BELFORT, M .

GENES & DEVELOPMENT, 1994, 8 (13) :1575-1588

[9] CONFORMATIONAL-CHANGES OF TRANSFER RIBONUCLEIC-ACID - RELAXATION KINETICS OF EARLY MELTING TRANSITION OF METHIONINE TRANSFER RIBONUCLEIC-ACID (ESCHERICHIA-COLI) [J].

COLE, PE ;

CROTHERS, DM .

BIOCHEMISTRY, 1972, 11 (23) :4368-&

[10] Folding mechanism of the Tetrahymena ribozyme P4-P6 domain [J].

Deras, ML ;

Brenowitz, M ;

Ralston, CY ;

Chance, MR ;

Woodson, SA .

BIOCHEMISTRY, 2000, 39 (36) :10975-10985

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