Self-Assembly of Responsive Multilayered DNA Nanocages

被引：87

作者：

Liu, Zhiyu ^{[1
]}

Tian, Cheng ^{[1
]}

Yu, Jinwen ^{[1
]}

Li, Yulin ^{[1
]}

Jiang, Wen ^{[2
,3
]}

Mao, Chengde ^{[1
]}

机构：

[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

[2] Purdue Univ, Markey Ctr Struct Biol, W Lafayette, IN 47907 USA

[3] Purdue Univ, Dept Biol Sci, W Lafayette, IN 47907 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2015年 / 137卷 / 05期

基金：

美国国家科学基金会;

关键词：

APTAMER;

D O I：

10.1021/ja5101307

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Here we report the assembly of multilayered DNA nanocages. The layers can be separated in response to a chemical cue, ATP. This is an effort to increase the structural complexity of DNA nanocages. The structures have been characterized by native polyacrylamide gel electrophoresis, atomic force microscopy, and cryogenic electron microscopy. We envision that the layer-by-layer assembly strategy used in this study can be easily applied to other DNA nanocages to form Russian-doll-like semisolid structures, while the chemically activated layer separation makes a contribution to the development of smart DNA nanocages.

引用

收藏

页码：1730 / 1733

页数：4

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