A Smart DNA Tetrahedron That Isothermally Assembles or Dissociates in Response to the Solution pH Value Changes

被引：73

作者：

Liu, Zhiyu ^{[1
]}

Li, Yingmei ^{[1
]}

Tian, Cheng ^{[1
]}

Mao, Chengde ^{[1
]}

机构：

[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

来源：

BIOMACROMOLECULES | 2013年 / 14卷 / 06期

关键词：

GOLD NANOPARTICLE; NANOMACHINE; POLYHEDRA; NANOSTRUCTURES; OCTAHEDRON; CHIRALITY; RELEASE; CARGO;

D O I：

10.1021/bm400426f

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This communication reports a DNA tetrahedron whose self-assembly is triggered by an acidic environment. The key element is the formation/dissociation of a short, cytosine (C)-containing, DNA triplex. As the solution pH value oscillates between 5.0 and 8.0, the DNA triplex will form and dissociate that, in turn, leads to assembly or disassembly of the DNA tetrahedron, which has been demonstrated by native polyacrylamide gel electrophoresis (PAGE). We believe that such environment-responsive behavior will be important for potential applications of DNA nanocages such as on-demand drug release.

引用

页码：1711 / 1714

页数：4

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