The NKG2D receptor: immunobiology and clinical implications

被引：83

作者：

Burgess, Steven J. ^{[1
]}

Maasho, Kerima ^{[1
]}

Masilamani, Madhan ^{[1
]}

Narayanan, Sriram ^{[1
]}

Borrego, Francisco ^{[1
]}

Coligan, John E. ^{[1
]}

机构：

[1] NIAID, Cell Biol Sect, Immunogenet Lab, Natl Inst Hlth, Rockville, MD 20852 USA

来源：

IMMUNOLOGIC RESEARCH | 2008年 / 40卷 / 01期

关键词：

natural killer cells; T cells; activating receptor; DAP10;

D O I：

10.1007/s12026-007-0060-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

NK cells are critical components of our immune system functioning, in part, to recognize and then eradicate virally infected or tumorigenic cells without previous sensitization. One of the best-characterized activating receptors expressed on NK cells is the NKG2D receptor, which is capable of transmitting co-stimulatory signals by subsets of T cells. Viruses and tumors have evolved strategies to evade NKG2D-mediated immune recognition thus highlighting the importance of this receptor in immunity. This review will focus on the structure of NKG2D and its interaction with its diverse array of ligands, as well as highlighting current knowledge regarding NKG2D signal transduction and biological mechanisms that govern its cell surface expression. The impact that NKG2D has in disease pathologies is also assessed.

引用

页码：18 / 34

页数：17

共 113 条

[101] IL-21 enhances tumor rejection through a NKG2D-dependent mechanism [J].

Takaki, R ;

Hayakawa, Y ;

Nelson, A ;

Sivakumar, PV ;

Hughes, S ;

Smyth, MJ ;

Lanier, LL .

JOURNAL OF IMMUNOLOGY, 2005, 175 (04) :2167-2173

[102]

THALE R, 1994, J VIROL, V68, P7757

[103] NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells [J].

Upshaw, JL ;

Arneson, LN ;

Schoon, RA ;

Dick, CJ ;

Billadeau, DD ;

Leibson, PJ .

NATURE IMMUNOLOGY, 2006, 7 (05) :524-532

[104] Role of NKG2D signaling in the cytotoxicity of activated and expanded CD8+ T cells [J].

Verneris, MR ;

Karami, M ;

Baker, J ;

Jayaswal, A ;

Negrin, RS .

BLOOD, 2004, 103 (08) :3065-3072

[105] CD28: A signalling perspective [J].

Ward, SG .

BIOCHEMICAL JOURNAL, 1996, 318 :361-377

[106] Selective intracellular retention of virally induced NKG2D ligands by the human cytomegalovirus UL16 glycoprotein [J].

Welte, SA ;

Sinzger, C ;

Lutz, SZ ;

Singh-Jasuja, H ;

Sampaio, KL ;

Eknigk, U ;

Rammensee, HG ;

Steinle, A .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2003, 33 (01) :194-203

[107] GENETIC-CONTROL OF AUTOIMMUNE DIABETES IN THE NOD MOUSE [J].

WICKER, LS ;

TODD, JA ;

PETERSON, LB .

ANNUAL REVIEW OF IMMUNOLOGY, 1995, 13 :179-200

[108] Crystal structure of the murine NK cell-activating receptor NKG2D at 1.95 Å [J].

Wolan, DW ;

Teyton, L ;

Rudolph, MG ;

Villmow, B ;

Bauer, S ;

Busch, DH ;

Wilson, IA .

NATURE IMMUNOLOGY, 2001, 2 (03) :248-254

[109] An activating immunoreceptor complex formed by NKG2D and DAP10 [J].

Wu, J ;

Song, YL ;

Bakker, ABH ;

Bauer, S ;

Spies, T ;

Lanier, LL ;

Phillips, JH .

SCIENCE, 1999, 285 (5428) :730-732

[110] Molecular cloning and characterization of pig immunoreceptor DAP10 and NKG2D [J].

Yim, D ;

Jie, HB ;

Sotiriadis, J ;

Kim, YS ;

Kim, KS ;

Rothschild, MF ;

Lanier, LL ;

Kim, YB .

IMMUNOGENETICS, 2001, 53 (03) :243-249

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