Dimerization of piceatannol by Momordica charantia peroxidase and α-glucosidase inhibitory activity of the biotransformation products

被引：35

作者：

Wan, Xiang ^{[1
]}

Wang, Xiao-Bing ^{[1
]}

Yang, Ming-Hua ^{[1
]}

Wang, Jun-Song ^{[1
]}

Kong, Ling-Yi ^{[1
]}

机构：

[1] China Pharmaceut Univ, Dept Nat Med Chem, Nanjing 210009, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2011年 / 19卷 / 17期

关键词：

Piceatannol; Momordica charantia peroxidase; Dimerization; alpha-Glucosidase inhibition; RESVERATROL; STILBENE; ACID;

D O I：

10.1016/j.bmc.2011.07.032

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Stilbenes, especially those oligomers, have great potential to be antihyperglycemic agents. In this study, eight stilbene dimers, including five new ones, were obtained by biotransformation of piceatannol using Momordica charantia peroxidase (MCP) for the first time. Their structures were established on the basis of spectroscopic evidences. These piceatannol dimers displayed potential a-glucosidase inhibitory activities, and trans double bond, tetrahydrofuran ring, and free adjacent phenolic dihydroxyls were found to be important for their activities. Enzymatic biotransformation of stilbenes by M. charantia peroxidase (MCP) was showed to be a prominent way to produce oligomeric stilbenes for antihyperglycemic development. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：5085 / 5092

页数：8

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