Apelin, a promising target for type 2 diabetes treatment?

被引：123

作者：

Castan-Iaurell, Isabelle ^{[1
,2
]}

Dray, Cedric ^{[1
,2
]}

Knauft, Claude ^{[1
,2
]}

Kunduzova, Oxana ^{[1
,2
]}

Valet, Philippe ^{[1
,2
]}

机构：

[1] Fac Med Toulouse, INSERM, U1048, F-31073 Toulouse, France

[2] Univ Toulouse 3, Inst Malad Metab & Cardiovasc I2MC, Univ Toulouse, F-31432 Toulouse 4, France

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2012年 / 23卷 / 05期

关键词：

INHIBITS INSULIN-SECRETION; FATTY-ACID OXIDATION; ADIPOSE-TISSUE; MITOCHONDRIAL BIOGENESIS; SKELETAL-MUSCLE; GLUCOSE-UPTAKE; PLASMA APELIN; APJ RECEPTOR; LIGAND; RESISTANCE;

D O I：

10.1016/j.tem.2012.02.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Insulin resistance is a main feature of obesity and type 2 diabetes mellitus (T2DM). Several mechanisms linking obesity to insulin resistance have been proposed. Adipose tissue modulates metabolism by secreting a variety of factors, which exhibit altered production during obesity. Apelin, a small peptide present in a number of tissues and also produced and secreted by adipocytes, has emerged as a new player with potent functions in energy metabolism, and in insulin sensitivity improvement. In this review, we describe the various metabolic functions that are affected by apelin and we present an integrated overview of recent findings that collectively propose apelin as a promising target for the treatment of T2DM.

引用

页码：234 / 241

页数：8

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