Engineering the Polymer Backbone To Strengthen Nonfouling Sulfobetaine Hydrogels

We have demonstrated that molecularly engineering the chemical structure of a monomer can lead to hydrogels with improved mechanical strength In this case, hydrogels from zwitterionic sulfobetaine methacrylate monomeis were compared to sulfobetaine vinylimidazole (pSBVI) hydrogels We show that the introduction of the vinylimidazole backbone improves the tensile and compressive mechanical properties of the sulfobetaine hydrogel by an older of magnitude over the same properties of a methacrylate hydrogel Zwitterionic groups have been shown to create surface coating materials with ultralow fouling propel ties, and we demonstrate here that the presence of the imidazole group does not compromise the nonfouling properties attributed to the zwitterionic sulfobetaine: surfaces coated with pSBVI exhibited exceptionally low nonspecific protein adsorption, and cell adhesion was reduced by 97% relative to lowfouling poly(2-hydroxyethyl methacrylate) (pHEMA) hydrogels