Mutual Interaction and Reciprocal Down-Regulation Between c-met and Insulin Receptor Substrate-1

被引：5

作者：

Deangelis, Tiziana ^{[1
]}

Morrione, Andrea ^{[2
]}

Baserga, Renato ^{[1
]}

机构：

[1] Thomas Jefferson Univ, Dept Canc Biol, Kimmel Canc Ctr, Philadelphia, PA 19107 USA

[2] Thomas Jefferson Univ, Dept Urol, Philadelphia, PA 19107 USA

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2010年 / 224卷 / 03期

关键词：

GROWTH-FACTOR-I; INSULIN-RECEPTOR-SUBSTRATE-1; IRS-1; CELL-DEATH; TRANSFORMATION; EXPRESSION; DIFFERENTIATION; OVEREXPRESSION; INTERLEUKIN-4; TUMORIGENESIS; INHIBITION;

D O I：

10.1002/jcp.22164

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

The insulin receptor substrate-1 (IRS-1) and c-met, the receptor for the hepatocyte growth factor (HGF) co-immuno-precipitate from lysates treated with the respective antibodies. The interaction between IRS-1 and c-met requires a tyrosyl phosphorylated IRS-1 and results in reciprocal down-regulation. IRS-1 inhibits cell motility, while the activated c-met promotes it. These and other results suggest an explanation for reports in the literature indicating that c-met levels are high and IRS-1 levels are low in human cancer metastases. J. Cell. Physiol. 224: 658-663, 2010. (C) 2010 Wiley-Liss, Inc.

引用

页码：658 / 663

页数：6

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