Eu.Gene Analyzer a tool for integrating gene expression data with pathway databases

被引：31

作者：

Cavalieri, Duccio ^{[1
]}

Castagnini, Cinzia

Toti, Simona

Maciag, Karolina

Kelder, Thomas

Gambineri, Luca

Angioli, Samuele

Dolara, Piero

机构：

[1] Univ Florence, Dept Preclin & Clin Pharmacol, Florence, Italy

[2] Univ Florence, Dept Stat, Florence, Italy

[3] Univ Maastricht, BIGCAT Bioinformat, Maastricht, Netherlands

[4] Inspect It, Capolona, Arezzo, Italy

来源：

BIOINFORMATICS | 2007年 / 23卷 / 19期

关键词：

D O I：

10.1093/bioinformatics/btm333

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Motivation: Eu. Gene Analyzer is an easy-to-use, stand-alone application that allows rapid and powerful microarray data analysis in the context of biological pathways. Its intuitive graphical user interface makes it an easy and flexible tool, even for the first-time user. Eu. Gene supports a variety of array platforms, organisms and pathway ontologies, transparently deals with multiple nomenclature systems and seamlessly integrates data from different sources. Two different statistical methods, the Fisher Exact Test and the Gene Set Enrichment Analysis (GSEA), are implemented to identify biological pathways transcriptionally affected under experimental conditions. A suite of tools is offered to define, visualize and share custom non-redundant pathway sets. In conclusion, Eu. Gene Analyzer is a new software application that takes advantage of information from multiple pathway databases to build a comprehensive interpretation of experimental results in a simple, intuitive environment.

引用

页码：2631 / 2632

页数：2

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