Long QT syndrome: novel insights into the mechanisms of cardiac arrhythmias

被引：92

作者：

Kass, RS

Moss, AJ

机构：

[1] Columbia Univ, Coll Phys & Surg, Dept Pharmacol, New York, NY 10032 USA

[2] Univ Rochester, Sch Med & Dent, Dept Med, Heart Res Follow Up Program, Rochester, NY 14642 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2003年 / 112卷 / 06期

关键词：

D O I：

10.1172/JCI200319844

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The congenital long QT syndrome is a rare disorder in which mutation carriers are at risk for polymorphic ventricular tachycardia and/or sudden cardiac death. Discovery and analysis of gene mutations associated with variants of this disorder have provided novel insight into mechanisms of cardiac arrhythmia and have raised the possibility of mutation-specific therapeutic intervention.

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页码：810 / 815

页数：6

相关论文

共 34 条

[11] Molecular and cellular mechanisms of cardiac arrhythmias [J].

Keating, MT ;

Sanguinetti, MC .

CELL, 2001, 104 (04) :569-580

[12] CONGENITAL DEAF-MUTISM, PROLONGED QT INTERVAL, SYNCOPAL ATTACKS AND SUDDEN DEATH [J].

LEVINE, SA ;

WOODWORTH, CR .

NEW ENGLAND JOURNAL OF MEDICINE, 1958, 259 (09) :412-417

[13] Age- and sex-related differences in clinical manifestations in patients with congenital long-QT syndrome - Findings from the international LQTS registry [J].

Locati, EH ;

Zareba, W ;

Moss, AJ ;

Schwartz, PJ ;

Vincent, GM ;

Lehmann, MH ;

Towbin, JA ;

Priori, SG ;

Napolitano, C ;

Robinson, JL ;

Andrews, M ;

Timothy, K ;

Hall, WJ .

CIRCULATION, 1998, 97 (22) :2237-2244

[14] Molecular basis of an inherited epilepsy [J].

Lossin, C ;

Wang, DW ;

Rhodes, TH ;

Vanoye, CG ;

George, AL .

NEURON, 2002, 34 (06) :877-884

[15] Calcium and the heart: a question of life and death [J].

Marks, AR .

JOURNAL OF CLINICAL INVESTIGATION, 2003, 111 (05) :597-600

[16] Requirement of a macromolecular signaling complex for β adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel [J].

Marx, SO ;

Kurokawa, J ;

Reiken, S ;

Motoike, H ;

D'Armiento, J ;

Marks, AR ;

Kass, RS .

SCIENCE, 2002, 295 (5554) :496-499

[17] Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death [J].

Mohler, PJ ;

Schott, JJ ;

Gramolini, AO ;

Dilly, KW ;

Guatimosim, S ;

duBell, WH ;

Haurogné, K ;

Kyndt, F ;

Ali, ME ;

Rogers, TB ;

Lederer, WJ ;

Escande, D ;

Le Marec, H ;

Bennett, V .

NATURE, 2003, 421 (6923) :634-639

[18] THE LONG QT SYNDROME - PROSPECTIVE LONGITUDINAL-STUDY OF 328 FAMILIES [J].

MOSS, AJ ;

SCHWARTZ, PJ ;

CRAMPTON, RS ;

TZIVONI, D ;

LOCATI, EH ;

MACCLUER, J ;

HALL, WJ ;

WEITKAMP, L ;

VINCENT, GM ;

GARSON, A ;

ROBINSON, JL ;

BENHORIN, J ;

CHOI, SS .

CIRCULATION, 1991, 84 (03) :1136-1144

[19] Effectiveness and limitations of β-blocker therapy in congenital long-QT syndrome [J].

Moss, AJ ;

Zareba, W ;

Hall, WJ ;

Schwartz, PJ ;

Crampton, RS ;

Benhorin, J ;

Vincent, GM ;

Locati, EH ;

Priori, SG ;

Napolitano, C ;

Medina, A ;

Zhang, L ;

Robinson, JL ;

Timothy, K ;

Towbin, JA ;

Andrews, ML .

CIRCULATION, 2000, 101 (06) :616-623

[20] ECG T-WAVE PATTERNS IN GENETICALLY DISTINCT FORMS OF THE HEREDITARY LONG QT SYNDROME [J].

MOSS, AJ ;

ZAREBA, W ;

BENHORIN, J ;

LOCATI, EH ;

HALL, WJ ;

ROBINSON, JL ;

SCHWARTZ, PJ ;

TOWBIN, JA ;

VINCENT, GM ;

LEHMANN, MH ;

KEATING, MT ;

MACCLUER, JW ;

TIMOTHY, KW .

CIRCULATION, 1995, 92 (10) :2929-2934

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