Endemic Venezuelan equine encephalitis in the Americas: hidden under the dengue umbrella

被引:134
作者
Aguilar, Patricia V. [1 ,2 ]
Estrada-Franco, Jose G. [1 ,2 ]
Navarro-Lopez, Roberto [3 ]
Ferro, Cristina [4 ]
Haddow, Andrew D. [1 ,2 ]
Weaver, Scott C. [1 ,2 ]
机构
[1] Univ Texas Med Branch, Ctr Trop Dis, Inst Human Infect & Immun, Galveston, TX 77555 USA
[2] Univ Texas Med Branch, Dept Pathol, Galveston, TX USA
[3] Comis Mexico Estados Unidos Prevenc Fiebre Aftosa, Mexico City, DF, Mexico
[4] Inst Nacl Salud, Bogota, Colombia
关键词
alphavirus; encephalitis; endemic; epizootic; mosquito; surveillance; PERUVIAN MOSQUITOS DIPTERA; VIRUS SUBTYPE IE; ENCEPHALOMYELITIS VIRUS; VECTOR COMPETENCE; ENVELOPE GLYCOPROTEIN; SOUTH-AMERICA; EXPERIMENTAL TRANSMISSION; GEOGRAPHIC-DISTRIBUTION; EXPERIMENTAL INFECTION; SENTINEL HAMSTERS;
D O I
10.2217/FVL.11.50
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Venezuelan equine encephalitis (VEE) is an emerging infectious disease in Latin America. Outbreaks have been recorded for decades in countries with enzootic circulation, and the recent implementation of surveillance systems has allowed the detection of additional human cases in countries and areas with previously unknown VEE activity. Clinically, VEE is indistinguishable from dengue and other arboviral diseases and confirmatory diagnosis requires the use of specialized laboratory tests that are difficult to afford in resource-limited regions. Thus, the disease burden of endemic VEE in developing countries remains largely unknown, but recent surveillance suggests that it may represent up to 10% of the dengue burden in neotropical cities, or tens-of-thousands of cases per year throughout Latin America. The potential emergence of epizootic viruses from enzootic progenitors further highlights the need to strengthen surveillance activities, identify mosquito vectors and reservoirs and develop effective strategies to control the disease. In this article, we provide an overview of the current status of endemic VEE that results from spillover of the enzootic cycles, and we discuss public health measures for disease control as well as future avenues for VEE research.
引用
收藏
页码:721 / 740
页数:20
相关论文
共 118 条
[61]   Venezuelan Equine Encephalitis Virus in Iquitos, Peru: Urban Transmission of a Sylvatic Strain [J].
Morrison, Amy C. ;
Forshey, Brett M. ;
Notyce, Desiree ;
Astete, Helvio ;
Lopez, Victor ;
Rocha, Claudio ;
Carrion, Rebecca ;
Carey, Cristhiam ;
Eza, Dominique ;
Montgomery, Joel M. ;
Kochel, Tadeusz J. .
PLOS NEGLECTED TROPICAL DISEASES, 2008, 2 (12)
[62]   Geographic distribution of Venezuelan equine encephalitis virus subtype IE genotypes in Central America and Mexico [J].
Oberste, MS ;
Schmura, SM ;
Weaver, SC ;
Smith, JF .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1999, 60 (04) :630-634
[63]   Association of Venezuelan equine encephalitis virus subtype IE with two equine epizootics in Mexico [J].
Oberste, MS ;
Fraire, M ;
Navarro, R ;
Zepeda, C ;
Zarate, ML ;
Ludwig, GV ;
Kondig, JF ;
Weaver, SC ;
Smith, JF ;
Rico-Hesse, R .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1998, 59 (01) :100-107
[64]  
Ortiz DI, 2008, J MED ENTOMOL, V45, P1117, DOI 10.1603/0022-2585(2008)45[1117:SOAADC]2.0.CO
[65]  
2
[66]   Replication and clearance of Venezuelan equine encephalitis virus from the brains of animals vaccinated with chimeric SIN/VEE viruses [J].
Paessler, S ;
Ni, HL ;
Petrakova, O ;
Fayzulin, RZ ;
Yun, N ;
Anishchenko, M ;
Weaver, SC ;
Frolov, I .
JOURNAL OF VIROLOGY, 2006, 80 (06) :2784-2796
[67]   Recombinant Sindbis/Venezuelan equine encephalitis virus is highly attenuated and immunogenic [J].
Paessler, S ;
Fayzulin, RZ ;
Anishchenko, M ;
Greene, IP ;
Weaver, SC ;
Frolov, I .
JOURNAL OF VIROLOGY, 2003, 77 (17) :9278-9286
[68]   Vaccines for Venezuelan equine encephalitis [J].
Paessler, Slobodan ;
Weaver, Scott C. .
VACCINE, 2009, 27 :D80-D85
[69]   ISOLATION OF VACCINE STRAIN OF VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS FROM MOSQUITOS IN LOUISIANA [J].
PEDERSEN, CE ;
ROBINSON, DM ;
COLE, FE .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1972, 95 (05) :490-&
[70]   Long-term duration of detectable neutralizing antibodies after administration of live-attenuated VEE vaccine and following booster vaccination with inactivated VEE vaccine [J].
Pittman, PR ;
Makuch, RS ;
Mangiafico, JA ;
Cannon, TL ;
Gibbs, PH ;
Peters, CJ .
VACCINE, 1996, 14 (04) :337-343