Exploring Primary Liver Macrophages for Studying Quantum Dot Interactions with Biological Systems

被引：79

作者：

Fischer, Hans C. ^{[1
,2
]}

Hauck, Tanya S. ^{[1
]}

Gomez-Aristizabal, Alejandro ^{[3
]}

Chan, Warren C. W. ^{[1
,2
]}

机构：

[1] Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON M5S 3G9, Canada

[2] Univ Toronto, Dept Mat Sci & Engn, Toronto, ON M5S 3G9, Canada

[3] Univ Toronto, Dept Dent, Toronto, ON M5G 1G6, Canada

来源：

ADVANCED MATERIALS | 2010年 / 22卷 / 23期

基金：

加拿大自然科学与工程研究理事会;

关键词：

LONG-TERM FATE; PLASMA-PROTEINS; KUPFFER CELLS; RAT-LIVER; KINETICS; BIODISTRIBUTION; TOXICITY; SIZE; PHARMACOKINETICS; PROLIFERATION;

D O I：

10.1002/adma.200904231

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

The effect quantum dots have on primary rat macrophages is investigated, and the findings are compared to in vivo data. In vitro uptake kinetics and degradation both reflect in vivo findings; therefore, primary macrophages are shown to be an appropriate system with which to investigate cellular responses to quantum dots and other nanoparticles in order to guide in vivo studies.

引用

页码：2520 / 2524

页数：5

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