Biocompatibility of modified polyethersulfone membranes by blending an amphiphilic triblock co-polymer of poly(vinyl pyrrolidone)-b-poly(methyl methacrylate)-b-poly(vinyl pyrrolidone)

被引:187
作者
Ran, Fen [1 ,2 ,3 ]
Nie, Shengqiang [1 ,2 ]
Zhao, Weifeng [1 ,2 ]
Li, Jie [3 ]
Su, Baihai [1 ]
Sun, Shudong [1 ]
Zhao, Changsheng [1 ,2 ]
机构
[1] Sichuan Univ, Coll Polymer Sci & Engn, State Key Lab Polymer Mat Engn, Chengdu 610065, Peoples R China
[2] Sichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610065, Peoples R China
[3] Lanzhou Univ Technol, State Key Lab Gansu Adv Nonferrous Met Mat, Lanzhou 730050, Peoples R China
基金
中国国家自然科学基金;
关键词
Polyethersulfone membrane; Amphiphilic triblock co-polymer; Ultrafiltration; Blood compatibility; Cytocompatibility; CONTROLLED/LIVING RADICAL POLYMERIZATION; PES ULTRAFILTRATION MEMBRANES; VITRO BLOOD COMPATIBILITY; BLOCK-COPOLYMERS; N-VINYLPYRROLIDONE; IN-VITRO; POLY(ETHYLENE GLYCOL); HEMODIALYSIS MEMBRANE; PHOSPHOLIPID POLYMER; SURFACE MODIFICATION;
D O I
10.1016/j.actbio.2011.05.026
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
An amphiphilic triblock co-polymer of poly(vinyl pyrrolidone)-b-poly(methyl methacrylate)-b-poly(vinyl pyrrolidone) (PVP-b-PMMA-b-PVP) was synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization. The block co-polymer can be directly blended with polyethersulfone (PES) using dimethylacetamide (DMAC) as the solvent to prepare flat sheet and hollow fiber membranes using a liquid-liquid phase separation technique. The PVP block formed a brush on the surface of the blended membrane, while the PMMA block mingled with the PES macromolecules, which endowed the membrane with permanent hydrophilicity. After adding the as-prepared block co-polymer the modified membranes showed lower protein (bovine serum albumin) adsorption, suppressed platelet adhesion, and a prolonged blood coagulation time, and thereby the blood compatibility was improved. Furthermore, the modified PES membranes showed good cytocompatibility, ultrafiltration and protein anti-fouling properties. These results suggest that surface modification of PES membranes by blending with the amphiphilic triblock co-polymer PVP-b-PMMA-b-PVP allows practical application of these membranes with good biocompatibility in the field of blood purification, such as hemodialysis and bio-artificial liver support. (C) 2011 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:3370 / 3381
页数:12
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