Novel coumarin derivatives of heterocyclic compounds as lipid-lowering agents

被引:116
作者
Madhavan, GR
Balraju, V
Mallesham, B
Chakrabarti, R
Lohray, VB
机构
[1] Dr Reddys Discovery Res, Discovery Chem, Hyderabad 500050, Andhra Pradesh, India
[2] Dr Reddys Discovery Res, Discovery Biol, Hyderabad 500050, Andhra Pradesh, India
关键词
D O I
10.1016/S0960-894X(03)00490-6
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Coumarin derivatives of different heterocycles (5,7a-i, 10 and 11) were designed based on cyclisation of 2-ethoxy-3phenylpropanoic acid and 2-benzylmalonic acid as novel lipid-lowering agents and their preliminary in vivo screening indicates 7c has moderate triglyceride-lowering activity. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码:2547 / 2551
页数:5
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