Trierixin, a novel inhibitor of ER stress-induced XBP1 activation from Streptomyces sp -: II. structure elucidation

被引：25

作者：

Futamura, Yushi

Tashiro, Etsu

Hironiwa, Naoka

Kohno, Jun

Nishio, Maki

Shindo, Kazutoshi

Imoto, Masaya

机构：

[1] Keio Univ, Fac Sci & Technol, Dept Biosci & Informat, Kohoku Ku, Yokohama, Kanagawa 2238522, Japan

[2] Japan Womens Univ, Dept Food & Nutr, Bunkyo Ku, Tokyo 1128681, Japan

[3] Tanabe Seiyaku Co Ltd, Discovery Res Labs, Toda, Saitama 3358505, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2007年 / 60卷 / 09期

关键词：

trierixin; triene-ansamycin; ER stress; XBP1;

D O I：

10.1038/ja.2007.74

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Trierixin, a new member of the triene-ansamycin group, has been isolated from the fermentation broth of Streptomyces sp. AC654 as an inhibitor of ER stress-induced XBP1 activation. The structure of trierixin was determined on the basis of its spectroscopical and chemical properties. Trierixin possessed a 21-membered macrocyclic lactam, which contains a methylthio-benzenediol structure, and a cyclohexanecarbonylalanine moiety. Trierixin is thus elucidated as 21-thiomethylmycotrienin II.

引用

页码：582 / 585

页数：4

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