Antiproliferative Alkaloids from Crinum zeylanicum

被引：42

作者：

Berkov, Strahil ^{[1
,2
]}

Romani, Stefania ^{[3
]}

Herrera, Maria ^{[4
]}

Viladomat, Francesc ^{[1
]}

Codina, Carles ^{[1
]}

Momekov, Georgi ^{[5
]}

Ionkova, Iliana ^{[5
]}

Bastida, Jaume ^{[1
]}

机构：

[1] Univ Barcelona, Fac Farm, Dept Prod Nat Biol Vegetal & Edafol, E-08028 Barcelona, Catalonia, Spain

[2] AgroBioInstitute, Sofia 1164, Bulgaria

[3] Univ Barcelona, Fac Farm, Dept Quim Farmaceut, E-08028 Barcelona, Catalonia, Spain

[4] Univ Camaguey, Fac Quim, Dept Quim, Camaguey, Cuba

[5] Med Univ Sofia, Fac Pharm, Sofia 1000, Bulgaria

来源：

PHYTOTHERAPY RESEARCH | 2011年 / 25卷 / 11期

关键词：

Crinum zeylanicum; Amaryllidaceae alkaloids; apoptosis; cytotoxicity; AMARYLLIDACEAE ALKALOIDS; CYTOTOXIC ACTIVITY; APOPTOSIS; LYCORINE; EXTRACTS; CELLS; DRUG;

D O I：

10.1002/ptr.3468

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Crinum zeylanicum is used in folk medicine as a rubefacient in rheumatism, a treatment for malaria or as a poison. Complex alkaloid profiles in C. zeylanicum plant organs were revealed by GC-MS analysis, including several bioactive compounds. Crinine, lycorine, 11-O-acetoxyambelline, ambelline, 6-hydroxybuphanidrine and 6-ethoxybuphanidrine (an artefact of the isolation procedure) were isolated. Crinine, 6-hydroxybuphanidrine and 6-ethoxybuphanidrine showed antiproliferative effects against human tumor cell lines, crinine being the most active (IC50 14.04 mu M against HL-60/Dox). The latter compound induced apoptosis in a dose-dependent manner in HL-60 and MDA-MB-231 cell lines. Structure-activity relationships in the studied molecules indicated that the hydrogenation of the double bond at C1-C2 leads to a loss of activity, whereas substitutions at C6, C8 and C11 affect their cytotoxicity. Copyright (C) 2011 John Wiley & Sons, Ltd.

引用

页码：1686 / 1692

页数：7

共 29 条

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Alkaloid Diversity in Galanthus elwesii and Galanthus nivalis [J].