Cytotoxic and antimalarial alkaloids from Brunsvigia littoralis

被引：82

作者：

Campbell, WE ^{[1
]}

Nair, JJ

Gammon, DW

Bastida, J

Codina, C

Viladomat, F

Smith, PJ

Albrecht, CF

机构：

[1] Univ Cape Town, Dept Chem, ZA-7700 Rondebosch, South Africa

[2] Univ Barcelona, Dept Nat Prod, E-08007 Barcelona, Spain

[3] Univ Cape Town, Dept Pharmacol, Observatory, South Africa

[4] Univ Stellenbosch, Dept Pharmacol, ZA-7505 Tygerberg, South Africa

来源：

PLANTA MEDICA | 1998年 / 64卷 / 01期

关键词：

D O I：

10.1055/s-2006-957381

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four known alkaloids, lycorine (1), 1,2-di-O-acetyllycorine (2), ambelline (3), and crinine (4) were isolated from the bulbs of Brunsvigia littoralis (Amaryllidaceae), H-1- and C-13-NMR spectra of 2 were completely assigned by means of ID- and 2D-NMR techniques, The alkaloids (1-4) together with the synthesised 11-O-acetylambelline (3a) and 3-O-acetylcrinine (4a) were tested for antimalarial activity with two strains of cultured Plasmodium falciparum and for cytotoxicity with BL6 mouse melanoma cells. Structures 1 and 2 exhibited both antimalarial and cytotoxic activity.

引用

页码：91 / 93

页数：3

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