Chipping away at the lung cancer genome

被引：164

作者：

Pao, William ^{[1
,2
]}

Hutchinson, Katherine E. ^{[3
]}

机构：

[1] Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Nashville, TN 37212 USA

[2] Vanderbilt Univ, Sch Med, Dept Med, Div Hematol Oncol, Nashville, TN 37212 USA

[3] Vanderbilt Univ, Sch Med, Dept Canc Biol, Nashville, TN 37212 USA

来源：

NATURE MEDICINE | 2012年 / 18卷 / 03期

关键词：

FUSIONS; RET; MUTATIONS; GENE; ACTIVATION; ALK;

D O I：

10.1038/nm.2697

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Kinase inhibitors are now standard treatment for patients with lung cancer whose tumors harbor specific mutant kinases. Four recent studies, including three in this issue (pages 375-384), have identified new fusion proteins involving another receptor tyrosine kinase that may potentially be responsive to existing targeted therapies.

引用

页码：349 / 351

页数：3

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