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Association between polymorphisms in the dopamine transporter gene and depression - Evidence for a gene-environment interaction in a sample of juvenile detainees
被引:59
作者:
Haeffel, Gerald J.
[1
,2
,9
]
Getchell, Marya
Koposov, Roman A.
[3
]
Yrigollen, Carolyn M.
DeYoung, Colin G.
af Klinteberg, Britt
[4
]
Oreland, Lars
[5
]
Ruchkin, Vladislav V.
[6
,7
]
Grigorenko, Elena L.
[8
]
机构:
[1] Yale Univ, Ctr Child Study, New Haven, CT 06519 USA
[2] Harvard Univ, Cambridge, MA 02138 USA
[3] Univ Tromso, N-9001 Tromso, Norway
[4] Stockholm Univ, Stockholm, Sweden
[5] Uppsala Univ, S-75105 Uppsala, Sweden
[6] Karolinska Inst, S-10401 Stockholm, Sweden
[7] Skonviks Psychiat Clin, Sater, Sweden
[8] Moscow MV Lomonosov State Univ, Moscow, Russia
[9] Univ Notre Dame, Notre Dame, IN 46556 USA
关键词:
D O I:
10.1111/j.1467-9280.2008.02047.x
中图分类号:
B84 [心理学];
学科分类号:
04 ;
0402 ;
摘要:
Previous research has generated examples of how genetic and environmental factors can interact to create risk for psychopathology. Using a gene-by-environment (G x E) interaction design, we tested whether three polymorphisms in the dopamine transporter gene (DAT1, also referred to as SLC6A3, located at 5p15.33) interacted with maternal parenting style to predict first-onset episodes of depression. Participants were male adolescents (N = 176) recruited from a juvenile detention center in northern Russia. As hypothesized, one of the polymorphisms (rs40184) moderated the effect of perceived maternal rejection on the onset of major depressive disorder, as well as on suicidal ideation. Further, this G x E interaction was specific to depression; it did not predict clinically significant anxiety. These results highlight the need for further research investigating the moderating effects of dopaminergic genes on depression.
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页码:62 / 69
页数:8
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