Unprecedented, fully recyclable, solid-supported reagent for the kinetic resolution of racemic amines through enantioselective N-acetylation

被引：14

作者：

Arseniyadis, S

Subhash, PV

Valleix, A

Wagner, A

Mioskowski, C

机构：

[1] Univ Louis Pasteur Strasbourg 1, Fac Pharm, CNRS, Lab Synth Bioorgan, F-67401 Illkirch Graffenstaden, France

[2] CEA Saclay, Dept Biol Cellulaire & Mol, Serv Mol Marquees, F-91191 Gif Sur Yvette, France

来源：

CHEMICAL COMMUNICATIONS | 2005年 / 26期

关键词：

D O I：

10.1039/b504200c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The high-yielding synthesis and application of the first polymer supported reagent for the kinetic resolution (KR) of amines through enantioselective acetylation is described; this new supported chiral reagent allows the KR of primary amines with excellent selectivities at room temperature; moreover, this supported approach is highly efficient as the Merrifield-supported chiral scaffold can be quantitatively recovered and recycled.

引用

页码：3310 / 3312

页数：3

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